Description

Metoclopramide Injection stimulates motility of the upper gastrointestinal tract without stimulating gastric, biliary, or pancreatic secretions. Its mode of action is unclear. It seems to sensitive tissues to the action of of acetylcholine. The effect of metoclopramide on motility is not dependent on intact vagal innervation, but it can be abolished by anticholinergic drugs.

Metoclopramide is a centrally acting anti-vomiting (antiemetic) medication that stimulates the motility of the upper GI tract. It has minimal effect on the lower GI tract and colon. Metoclopramide increases peristalsis of the small intestine and increases tone and strength of contractions in the stomach while causing relaxation of the pyloric sphincter. Consequently, metoclopramide speeds gastric emptying and, possibly, intestinal transit times. It does not stimulate gastric, pancreatic or biliary secretions. It is used primarily for slow gastric motility and the treatment of vomiting.

Metoclopramide is used to treat

Nausea
Vomiting
Reflux Disease

Metoclopramide acts as a central antiemetic by blocking the uptake of dopamine at the chemo-receptor trigger zone in dogs. Additionally, part of its actions on the upper GI tract include increasing the sphincter pressure in the lower esophagus and reducing gastroesophageal reflux, which also may be helpful for decreasing vomiting.

Dosage

Dogs and Cats

0.2-0.5 mg/kg every 6-8 hours orally, IV or IM, or 1-2 mg/kg every 2-4 hours by continuous IV infusion, or approximately 0.1-0.2 mg/kg every hour.

Horses

0.125-0.25 mg/kg/hr IC [added to IV fluids].

by Hospira, Inc.

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Located in Hastings, Nebraska, Heartland Veterinary Supply & Pharmacy started as a Veterinary Clinic in 1981, specializing in the health and wellness of the equine, canine and feline species. We have a licensed Veterinarian and Pharmacist on site, as well as a helpful team with the knowledge and products you need to keep your horse, dog or cat healthy and happy. The Heartland Staff is dedicated to fast, courteous service.

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