Proin

How to Order Prescriptions

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Description

Proin is a chewable tablet supplemental product for urinary incontinence in dogs. Your veterinarian may recommend treatment with Proin® phenylpropanolamine hydrochloride (ppa). The active ingredient in Proin is an alpha agonist which is highly effective in the control of urinary incontinence.

 

Uses and Benefits

• Helps tighten the urethral sphincter, which helps to control urine leakage
• Proven "puddle" control
• Proven FDA-approved for control of urinary incontinence due to urethral sphincter hypotonus
• Easy To Administer Chewable, liver-flavored tablets improve compliance
• Ensures sustained phenylpropanolamine levels in the blood stream and may help reduce the conditions often associated with high levels of phenylpropanolamine such as: decreased appetite, changes in heart rate, increased blood pressure, hyperexcitability

How It Works

Proin contains the active ingredient phenylpropanolamine, an adrenergic agent that works by tightening the bladder sphincter muscle, which helps to control urine leakage.

Indications

PROIN is indicated for the control of urinary incontinence due to urethral sphincter hypotonus in dogs.

Active Ingredients

Phenylpropanolamine Hydrochloride

Directions

• Proin liver flavored chewable tablets are available by prescription for use in dogs to treat urinary incontinence.
• Proin may cause restlessness, irritability, or loss of appetite.
• Tell your veterinarian about any other medication you may be giving your pet.

Tip: Give this medication exactly as directed by your veterinarian. Do not exceed 1.8mg/lb per day. The medication may be given with food.

Weight Dosage

All weights          The usual dose for dogs is 0.4-0.8mg/pound every 12 hours.

Caution

Don't give Proin with ephedrine or epinephrine, and don't give it within two weeks of using a MAOi, such as Anipryl, selegiline or a Preventic Collar. Possible side effects can occur, including restlessness, or loss of appetite, difficulty breathing, hives, and swelling of the lips, tongue, or face. If these or any other side effects occur, contact your veterinarian immediately

Possible Side Effects

Stop giving Proin and contact your veterinarian immediately if your pet has an allergic reaction (difficulty breathing; swelling of the lips, tongue, face; and hives). Other side effects that may occur include restlessness, irritability, increased heart rate, increased blood pressure and loss of appetite. Continue to give the medication and contact your veterinarian. Other less serious side effects may occur. Contact your veterinarian about any side effects that seem bothersome.

Precautions

PROIN may cause increased thirst; therefore, provide ample fresh water.

Overdose has been associated with dogs chewing through closed bottles of PROIN and consuming multiple tablets. Therefore, it is important to store PROIN Chewable Tablets out of reach of dogs and other pets in a secured location.

Use in dogs with incontinence due to a urinary tract infection will mask symptoms. PROIN is not effective in dogs with incontinence due to neurologic disease or malformations.

PROIN may cause hypertension; therefore, use with caution in dogs with pre-existing heart disease, hypertension, liver disease, kidney insufficiency, diabetes, glaucoma, and conditions with a predilection for hypertension. Use with caution in dogs receiving sympathomimetic drugs, tricyclic antidepressants, or monoamine oxidase inhibitors as increased toxicity may result. Use with caution in dogs administered halogenated gaseous anesthetics as this may increase the risk of cardiac arrhythmias.

A laboratory study on human blood revealed that PPA used in conjunction with aspirin may potentiate decreased platelet aggregation.

The safe use of PROIN in dogs used for breeding purposes, during pregnancy or in lactating bitches, has not been evaluated.

Storage

Store at controlled room temperature 20-25°C (68-77°F), excursions permitted between 15-40°C (59-104°F)

How to Order Prescriptions

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Description

• A supplemental product for urinary incontinence in dogs.
• Your veterinarian may recommend treatment with Proin® phenylpropanolamine hydrochloride (ppa). The active ingredient in Proin is an alpha agonist which is highly effective in the control of urinary incontinence.

Proin is easy to administer on your pet’s food or as a treat. Your veterinarian will choose the formulation best suited to the needs of your dog.

Often the dosage can be gradually reduced after the dog is stabilized. However, this condition is not curable and the need for ongoing treatment is likely.

Benefits

• Flavored for easy administration – can be given as a treat
• Proven "puddle" control

by PRN