Zimecterin Gold Paste

Description

All horses should be included in a regular parasite control program with particular attention paid to mares, foals and yearlings. ZIMECTERIN Gold combines ivermectin, a leading ingredient that controls a wide variety of parasites, with praziquantel, an ingredient that specifically controls tapeworms. Together, they provide excellent equine parasite control. ZIMECTERIN Gold is approved to control more species and stages of equine parasites than any other brand, including benzimidazole-resistant small strongyles. It controls 47 species and stages of equine parasites in all. Plus, ZIMECTERIN Gold was the first dewormer approved by the FDA to effectively control tapeworms with a single dose. Tapeworms have been recognized as a significant threat to the health of horses.

Indications

Zimecterin Gold Paste (ivermectin/praziquantel) Paste provides effective treatment and control of the following parasites in horses:

Tapeworms: Anoplocephala perfoliata,
Large Strongyles (Adults): Strongylus vulgaris (also early forms in blood vessels), S. edentatus (also tissue stages), S. equinus, Triodontophorus spp. including T. brevicauda and T. serratus and Craterostomum acuticaudatum
Small Strongyles: (adults, including those resistant to some benzimidazole class compounds) – Coronocyclus spp. including C. coronatus, C. labiatus and C. labratus, Cyathostomum spp. including C. catinatum and C. pateratum, Cylicocyclus spp. including C. insigne, C. leptostomum, C. nassatus, and C. brevicapsulatus, Cylicodontophorus spp., Cylicostephanus spp., including C. calicatus, C. goldi, C. longibursatus and C. minutus, and Petrovinema poculatum
Small Strongyles: Fourth-stage larvae
Pinworms: (adults and fourth-stage larvae) – Oxyuris equi
Ascarids: (adults and third- and fourth-stage larvae) – Parascaris equorum
Hairworms (Adults): Trichostrongylus axei
Large-Mouth: arnfieldi
Intestinal Theadworms (Adults): Strongyloides westeri
Summer Sores: caused by Habronema and Draschia spp. cutaneous third-stage larvae; Dermatitis caused by neck threadworm microfilariae, Onchocerca sp.

Use

ZIMECTERIN Gold (ivermectin/praziquantel) is safe for adult horses and foals as young as 2 months of age. Each syringe contains enough paste to treat one 1,250-pound horse at the recommended dose rate of 91 mcg ivermectin per pound (200 mcg/kg) body weight and 454 mcg praziquantel per pound (1 mg/kg) body weight. Each weight marking on the syringe plunger delivers enough paste to treat 250 pounds of body weight.

Dosage and Administration

This syringe contains sufficient paste to treat one 1250 lb horse at the recommended dose rate of 91 mcg ivermectin per lb (200 mcg/kg) body weight and 454 mcg praziquantel per lb (1 mg/kg) body weight. Each weight marking on the syringe plunger delivers enough paste to treat 250 lb body weight.

1. While holding plunger, turn the knurled ring on the plunger 1/4 turn to the left and slide it so the side nearest the barrel is at the prescribed weight marking.
2. Lock the ring in place by making a 1/4 turn to the right.
3. Make sure that the horse's mouth contains no feed.
4. Remove the cover from the tip of the syringe.
5. Insert the syringe tip into the horse's mouth at the space between the teeth.
6. Depress the plunger as far as it will go, depositing paste on the back of the tongue.
7. Immediately raise the horse's head for a few seconds after dosing.

Animal Safety

ZIMECTERIN® GOLD Paste may be used in horses two months of age or older. ZIMECTERIN® GOLD Paste has not been tested in foals younger than two months of age, mares at or near the time of breeding, pregnant or lactating mares, and breeding stallions.

ZIMECTERIN® GOLD Paste, when tested at 1, 3 and 5-times the maximum recommended dose every two weeks in 5-month old foals, and at 10-times the maximum recommended dose in a separate study, did not elicit any adverse clinical signs of toxicity. In a foal safety study in younger animals, ZIMECTERIN® GOLD Paste was found safe at up to 3-times the maximum recommended dose in 2-month old foals.

Warnings

DO NOT USE IN HORSES INTENDED FOR HUMAN CONSUMPTION.

NOT FOR USE IN HUMANS. KEEP THIS AND ALL DRUGS OUT OF REACH OF CHILDREN.

 

Human Warnings

Not for use in humans. Keep this and all drugs out of the reach of children. Refrain from eating or smoking when handling. Wash hands after use. Avoid contact with eyes. The Material Safety Data Sheet (MSDS) contains more detailed occupational safety information. To report adverse reactions in users, to obtain more information, or to obtain a MSDS, contact Merial at 1-888-637-4251.

Precautions

ZIMECTERIN® GOLD (ivermectin/praziquantel) Paste has been formulated specifically for use in horses only. This product should not be used in other animal species as severe adverse reactions, including fatalities in dogs, may result.

Post-Approval Experience

Although not all adverse reactions are reported, the following reactions are based on voluntary post-approval drug experience reporting. There have been rare reports of swelling and irritation of the mouth, lips, and tongue following administration of ZIMECTERIN® GOLD. These reactions have been transitory in nature.

Environmental Safety

Ivermectin and excreted ivermectin residues may adversely affect aquatic organisms. Do not contaminate ground or surface water. Dispose of the syringe in an approved landfill or by incineration.

Information for Horse Owners

Swelling and itching reactions after treatment with ivermectin have occurred in horses carrying heavy infections of neck threadworm (Onchocerca sp.) microfilariae. These reactions were most likely the result of microfilariae dying in large numbers. Symptomatic treatment may be advisable. Consult your veterinarian should any such reactions occur. Healing of summer sores involving extensive tissue changes may require other appropriate therapy in conjunction with treatment with ZIMECTERIN® GOLD Paste. Reinfection, and measures for its prevention, should also be considered. Consult your veterinarian if the condition does not improve.

Storage

Store up to 86°F (30°C). Transient exposure to temperatures up to 104°F (40°C) is permitted.