Description

NOBIVAC® Lepto4  has been shown to be effective for vaccination of healthy dogs 8 weeks of age or older against Leptospira canicola, L. icterohaemorrhagiae, L. pomona, and L. grippotyphosa. Duration of immunity has not been established. This product has also been shown to be effective against mortality and leptospiruria (shedding of Leptospira in the urine) caused by L. canicola, L. icterohaemorrhagiae, L. pomona, and L. grippotyphosa.

Benefits

• Shown to be effective in the prevention of disease and mortality caused by 4 virulent Leptospira serovars2
• Protects against liver dysfunction and thrombocytopenia3
• The only vaccine shown to be 100% effective against mortality and urinary shedding of all 4 serovars
• Protects against leptospiremia1
• Proven safe and well-tolerated in multiple studies3
• Available in both a monovalent and combination formulation (DAPPv)

Dosage and Administration

• Subcutaneous injection
• Two 1-mL doses given 2 to 4 weeks apart
• Last dose may be given at 12 weeks of age
• Annual revaccination with 1 dose is recommended
• Available in a 25 x 1-mL dose

WARNINGS:

• Contains gentamicin and amphotericin B as preservatives.
• Vaccinate only healthy, non-parasitized dogs.
• This product has not been tested in pregnant bitches.
• The use of a biological product may produce anaphylaxis and or other inflammatory immune-mediated hypersensitivity reactions. Antidote: Epinephrine, corticosteroids, and antihistamines may all be indicated depending on the nature and severity of the reaction.

Nobivac Lepto 4 is a registered trademark of Intervet Inc., d/b/a Merck Animal Health, a subsidiary of Merck & Co. Inc.

Features and benefits

• Prevented mortality caused by 4 virulent Leptospira serovars¹
• Clinical efficacy results showed that Nobivac Lepto₄ prevented liver dysfunction and thrombocytopenia¹
• The only vaccine proven to protect against mortality and leptospiruria
• Significantly reduced leptospiremia¹
• Proven safe and well tolerated in multiple studies¹
• Available in 2 convenient forms

Dosage and administration

• Subcutaneous injection
• Two 1-mL doses given 2 to 4 weeks apart
• Last dose may be given at 12 weeks of age
• Annual revaccination with 1 dose is recommended
• Available in a 25 x 1-mL dose

Do no vaccinate pregnant dogs.

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