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Description

Veterinary pHyLyte™ Injection pH 7.4 (Multiple Electrolytes Injection, Type 1, USP) is a sterile, nonpyrogenic isotonic solution for fluid and electrolyte replenishment in single dose containers for intravenous administration. It contains no antimicrobial agents or preservatives. Discard unused portion. The pH is adjusted with sodium hydroxide.

Table 1: Veterinary pHyLyte™ Injection pH 7.4 (Multiple Electrolytes Injection, Type 1, USP) Composition (mg/100mL) Ionic Concentration (mEq/L) kcal/L
Size (mL) Sodium Chloride, USP
(NaCl) Sodium Gluconate, USP
(C6H11NaO7) Sodium Acetate Trihydrate, USP
(C2H3NaO2∙3H2O) Potassium Chloride, USP
(KCl) Magnesium Chloride, USP
(MgCl2∙6H2O) Osmolarity
(mOsmol/L) (calc) pH Sodium Potassium Magnesium Chloride Acetate Gluconate Caloric Content
1000 526 502 368 37 30 294 7.4
(6.5 to 8.0) 140 5 3 98 27 23 21

Clinical Pharmacology

Veterinary pHyLyte™ Injection pH 7.4 (Multiple Electrolytes Injection, Type 1, USP) administered intravenously has value as a source of water and electrolytes. It is capable of inducing diuresis, depending on the clinical condition of the patient.

Veterinary pHyLyte™ Injection pH 7.4 (Multiple Electrolytes Injection, Type 1, USP) produces a metabolic alkalinizing effect. Acetate and gluconate ions are metabolized ultimately to carbon dioxide and water, which requires the consumption of hydrogen cations.

Indications and Usage

Veterinary pHyLyte™ Injection pH 7.4 (Multiple Electrolytes Injection, Type 1, USP) is indicated as a source of water and electrolytes or as an alkalinizing agent.

Veterinary pHyLyte™ Injection pH 7.4 (Multiple Electrolytes Injection, Type 1, USP) is compatible with blood or blood components. It may be administered prior to or following the infusion of blood through the same administration set (i.e. as a priming solution), added to or infused concurrently with blood components, or used as a diluent in the transfusion of packed erythrocytes. Veterinary pHyLyte™ Injection pH 7.4 (Multiple Electrolytes Injection, Type 1, USP) and 0.9% Sodium Chloride Injection, USP are equally compatible with blood or blood components.

Contraindications

None known.

Warnings

Veterinary pHyLyte™ Injection pH 7.4 (Multiple Electrolytes Injection, Type 1, USP) should be used with great care, if at all, in patients with congestive heart failure, severe renal insufficiency, and in clinical states in which there exists edema with sodium retention.

Veterinary pHyLyte™ Injection pH 7.4 (Multiple Electrolytes Injection, Type 1, USP) should be used with great care, if at all, in patients with hyperkalemia, severe renal failure, and in conditions in which potassium retention is present.

Veterinary pHyLyte™ Injection pH 7.4 (Multiple Electrolytes Injection, Type 1, USP) should be used with great care in patients with metabolic or respiratory alkalosis. The administration of acetate or gluconate ions should be done with great care in those conditions in which there is an increased level or an impaired utilization of these ions, such as severe hepatic insufficiency.

The intravenous administration of Veterinary pHyLyte™ Injection pH 7.4 (Multiple Electrolytes Injection, Type 1, USP) can cause fluid and/or solute overloading resulting in dilution of serum electrolyte concentrations, overhydration, congested states, or pulmonary edema. The risk of dilutional states is inversely proportional to the electrolyte concentrations of the injection. The risk of solute overload causing congested states with peripheral and pulmonary edema is directly proportional to the electrolyte concentrations of the injection.

In patients with diminished renal function, administration of Veterinary pHyLyte™ Injection pH 7.4 (Multiple Electrolytes Injection, Type 1, USP) may result in sodium or potassium retention.

Precautions

Veterinary pHyLyte™ Injection pH 7.4 (Multiple Electrolytes Injection, Type 1, USP) should be used with caution. Excess administration may result in metabolic alkalosis.

Caution must be exercised in the administration of Veterinary pHyLyte™ Injection pH 7.4 (Multiple Electrolytes Injection, Type 1, USP) to patients receiving corticosteroids or corticotropin.

Do not administer unless solution is clear and seal is intact.

Use as directed by Vet


By Dechra