Midamox (imidacloprid + moxidection) Topical Solution for Dogs

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Description

Midamox for Dogs is used for the prevention of heartworm disease, treatment of Dirofilaria immitis circulating microflariae, kills adult fleas and is indicated for the treatment of flea infestations, treatment and control of hookworms, roundworms, and whipworms, and treatment of sarcoptic mange. This product is intended for dogs and puppies 7 weeks of age and older and 3 to 9 lbs.

Midamox for Dogs is also indicated for the treatment and control of the following intestinal parasites:

Intestinal Parasite		Intestinal Stage
		Adult	Immature Adult	Fourth Stage Larvae
Hookworm Species	Ancylystoma caninum	x	x	x
	Uncinaria stenocephala	x	x	x
Roundworm Species	Toxocara canis	x		x
	Toxasscaris leonina	x
Whipworm	Trichuris vulpis	x

Heartworm Prevention

For prevention of heartworm disease, Midamox for Dogs should be administered at one-month intervals. Midamox for Dogs may be administered year-round or at a minimum should start one month before the first expected exposure to mosquitoes and should continue at monthly intervals until one month after the last exposure to mosquitoes. If a dose is missed and a 30-day interval between doses is exceeded, administer Midamox for Dogs immediately and resume the monthly dosing schedule. When replacing another heartworm preventative product in a heartworm prevention program, the first treatment with Midamox for Dogs should be given within one month of the last dose of the former medication. 

Treatment of Circulating Microfilaria

For the treatment of circulating D. immitis microfilaria in heartworm-positive dogs, Midamox for Dogs should be administered at one-month intervals. Treatment with an approved adulticide therapy is recommended because Midamox for Dogs is not effective for the treatment of adult D. immitis. 

Flea Treatment

For the treatment of flea infestations, Midamox for Dogs should be administered at one-month intervals. If the dog is already infested with fleas when the first dose of Midamox for Dogs is administered, adult fleas on the dog will be killed. However, reinfestation from preexisting pupae in the environment may continue to occur for six weeks or longer after treatment is initiated. Dogs treated with imidacloprid, including those with pre-existing flea allergy dermatitis have shown clinical improvement as a direct result of elimination of fleas from the dog.

Treatment and Control of Intestinal Nematode Infections

For the treatment and control of intestinalis hookworm infections cause by Ancylostoma caninum and Uncinaria stenocephala (adults, immature adults and fourth stage larvae) and roundworm infections caused by Toxacara canis (adults and fourth stage larvae), and Toxascaris leonina (adults), and whipworm infections caused by Trixhuris vulpis (adults), Midamox for Dogs should be administered once as a single topical dose. 

Treatment and Control of Sarcoptic Mange

For the treatment and control of sarcoptic mange caused by Sarcoptes scabiei var. canis, Midamox for Dogs should be administered as a single topical dose. A second monthly dose may be administered if necessary. 

Dosage and Administration

The recommended minimum dose is 4.5mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration. Do not apply to irritated skin.

1. Remove the applicator from the outer pouch using scissors or fold among diagonal line to expose nick; tear back at nick. As specified in the following table, administer the entire contents of the Midamox for Dogs applicator that correctly corresponds with the body weight of the dog.

Dogs (lbs.)	Midamox for Dogs	Volume (mL)	Imidacloprid (mg)	Moxidectin (mg)
3-9	Midamox 9	0.4	40	10
9.1-20	Midamox 20	1.0	100	25
20.1-55	Midamox 55	2.5	250	62.5
55.1-88	Midamox 88	4.0	400	100
88.1-110*	Midamox 110	5.0	500	125

*Dogs over 110 lbs. should be treated with the appropriate combination of Midamox for Dogs.

2. Hold the applicator upright.
3. Tap the narrow part of the applicator to ensure the contents remain within the main body of the applicator. 
4. Twist or snap back the tip.
5. The dog should be standing for application. Part of the hair on the back of the dog between the shoulder blades until the skin is visible. For dogs weighing 20 lbs. or less, place the tip of the applicator on the skin at one spot between the shoulder blades. For dogs weighing more than 20 lbs., place the tip of the applicator on the skin and apply the entire contents directly on the exposed skin at 3 or 4 spots on the top of the backline from the base of the neck to the upper back in an area inaccessible to licking. Do not apply an amount of solution at any one location that could run off the side of the dog.

Do not let this product get in your dog's mouth or eyes. Do not allow the dog to lick any of the application sites for 30 minutes. In households with multiple pets, keep each treated dog separated from other treated dogs and other pets for 30 minutes after application to prevent licking the application sites.

Stiff hair, a damp appearance of the hair, pink skin, or a slightly powdery residue may be observed at the application site on some animals. This is temporary and does not affect the safety and effectiveness of the product. 

Shampooing 90 minutes after treatment does not reduce the effectiveness of Midamox for Dogs in the prevention of heartworm disease. Shampooing or water immersion 4 days after treatment will not reduce the effectiveness of Midamox for Dogs in the treatment of flea infestations. However, shampooing as often as once weekly may reduce the effectiveness of the product against fleas. 

Contraindications

Do not administer this product orally.
Do not use this product (containing 2.5% moxidectin) on cats.

Storage Information

Store below 77ºF (25ºC). Excursions are permitted up to 104ºF (40ºC) however such exposure should be minimized. Do not remove the applicator from the pouch until ready to use. Do not use after the expiration date which is stated on the carton.