Nexgard Plus Chewable Tablets for Dogs

How to Order Prescriptions

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Description

NexGard® PLUS is indicated for the prevention of heartworm disease caused by Dirofi laria immitis. NexGard® PLUS is indicated for the treatment and control of adult hookworm (Ancylostoma caninum, Ancylostoma braziliense, and Uncinaria stenocephala) and roundworm (Toxocara canis and Toxascaris leonina) infections. NexGard® PLUS kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of Ixodes scapularis (black-legged tick), Rhipicephalus sanguineus (brown dog tick), Dermacentor variabilis (American dog tick), and Amblyomma americanum (lone star tick) infestations for one month in dogs and puppies eight weeks of age and older, weighing four pounds of body weight or greater.

Dosage and Administration

NexGard® PLUS is given orally once a month at the minimum dosage of 1.14 mg/lb (2.5 mg/kg) afoxolaner, 5.45 mcg/lb (12 mcg/kg) moxidectin, and 2.27 mg/lb (5.0 mg/kg) pyrantel (as pamoate salt). For heartworm disease prevention, give once monthly for at least six months after last exposure to mosquitoes (see Effectiveness).

Dosing Schedule

Body Weight (lbs.)	Afoxolaner Per Chewable (mg)	Moxidectin Per Chewable (mcg)	Pyrantel* Per Chewable (mg)	Chewables Administered
4 to 8 lbs.	9.375	45	18.75	One
8.1 to 17 lbs.	18.75	90	37.5	One
17.1 to 33 lbs.	37.5	180	75	One
33.1 to 66 lbs.	75	360	150	One
66.1 to 132 lbs.	150	720	300	One
Ober 132 lbs.	Administer the appropriate combination of chewables

*As pamoate salt.

NexGard® PLUS can be administered with or without food. Care should be taken to ensure that the dog consumes the complete dose and that part of the dose is not lost or refused. If a dose is missed, administer NexGard® PLUS and resume a monthly dosing schedule.

Heartworm Prevention

NexGard® PLUS should be administered at monthly intervals year-round or, at a minimum, administration should start within one month of the dog’s first seasonal exposure to mosquitoes and should continue at monthly intervals until at least six months after the dog’s last exposure (see Effectiveness). When replacing another monthly heartworm preventive product, the first dose of NexGard® PLUS should be given within a month of the last dose of the former medication.

Flea Treatment and Prevention

NexGard® PLUS should be administered year-round at monthly intervals or started at least one month before fleas become active. To minimize the likelihood of flea re-infestation, it is important to treat all animals within a household with an approved flea control product.

Tick Treatment and Control

NexGard® PLUS should be administered year-round at monthly intervals or started at least one month before ticks become active.

Intestinal Nematode Treatment and Control

NexGard® PLUS treats and controls adult hookworms (Ancylostoma caninum, Ancylostoma braziliense, and Uncinaria stenocephala) and roundworms (Toxocara canis and Toxascaris leonina). For the treatment of adult hookworm and roundworm infections, NexGard® PLUS should be administered as a single dose. Monthly use of NexGard® PLUS will control any subsequent infections. Dogs may be exposed to and can become infected with hookworms and roundworms throughout the year, regardless of season or climate. 

Precautions

Afoxolaner, one of the ingredients in NexGard® PLUS, is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders.

Treatment with fewer than six monthly doses after the last exposure to mosquitoes has not been evaluated and may not provide complete heartworm prevention.

Prior to administration of NexGard® PLUS, dogs should be tested for existing heartworm infection. At the discretion of the veterinarian, infected dogs should be treated with an adulticide to remove adult heartworms. NexGard® PLUS is not effective against adult D. immitis. The safe use of NexGard® PLUS in breeding, pregnant, or lactating dogs has not been evaluated.

How Supplied

NexGard® PLUS is available in five strengths of beef-flavored soft chewables formulated according to the weight of the dog (see Dosage and Administration). Each chewable size is available in color-coded packages of 1, 3, or 6 chewables.

Storage Information

Store in original package at or below 30°C (86°F) with excursions permitted up to 40°C (104°F).